During his own lifetime, Francesca was also regarded as a skilled mathematician and geometer but after his passing these strings to his bow were played down. Leonardo da Vinci is probably the best known artist with a talent for mathematics, but others from the Renaissance were also involved in at various points. Others would take in architecture, literature, sculpture and engraving, with no real limit to the Renaissance movement as a whole.

It is only in recent centuries that Francesca has been regarded, first and foremost, as a painter. His work with theories on geometry and also perspective had previously dominated his legacy. Science is still evident in his art, however, from the way in which he meticulously put together his compositions. A downside with his work with installation frescos is that to a certain degree it has limited his publicity in major galleries and art museums, with much of his work hard to locate unless making a specific visit.

The key works from this painter can be found spread between his hometown of Sansepolcro, Arezzo, Rimini, Monterchi and Urbino. Many more have sadly been damaged or destroyed completely, particularly his significantly more fragile drawings. Indeed, a specific trail is now offered that takes in each of these locations as part of a tour. That is a problem which impacts most artists from the Renaissance, but those whose work could not be transported easily would always be more succeptable to damage from air raids or natural climatic effects.

Piero della Francesca would spend time in Florence, the biggest influence on the Italian Renaissance, and at this point would have come into contact with Fra Angelico, Donatello and possibly Paolo Uccello too. Additionally, this city played host to the likes of Luca della Robbia and Brunelleschi too.

The earlier work of Masaccio is known to have directly inspired Francesca and his style which was similarly classicist. It was Masaccio's work in the Santa Maria del Carmine that specifically had the most impact and helped to single out this Florentine as the first true master of the Italian Renaissance. Two other significant artists in the Papal States around this time were Andrea Mantegna and Giovanni Bellini.